Found 6 hits Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM427846' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427846
(US10544143, Example 279 | US10544143, Example 284 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)NC1COC1)-c1cc(C)c2ncnn2c1 |(2.06,3.14,;3.15,2.05,;4.63,2.45,;2.75,.56,;3.65,-.69,;2.75,-1.93,;1.28,-1.46,;-.05,-2.23,;-1.39,-1.46,;-1.39,.08,;-.05,.85,;1.28,.08,;-2.72,.85,;-4.05,.08,;-5.39,.85,;-5.39,2.39,;-4.05,3.16,;-2.72,2.39,;-6.72,3.16,;-8.05,2.39,;-9.54,2.79,;-9.94,1.31,;-8.45,.91,;5.19,-.69,;5.96,.65,;7.5,.65,;8.27,1.98,;8.27,-.69,;9.78,-1.01,;9.94,-2.54,;8.53,-3.16,;7.5,-2.02,;5.96,-2.02,)| Show InChI InChI=1S/C26H32N6O/c1-15(2)23-24(18-10-16(3)26-27-14-28-32(26)11-18)31-22-9-8-21(30-25(22)23)17-4-6-19(7-5-17)29-20-12-33-13-20/h8-11,14-15,17,19-20,29,31H,4-7,12-13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427846
(US10544143, Example 279 | US10544143, Example 284 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)NC1COC1)-c1cc(C)c2ncnn2c1 |(2.06,3.14,;3.15,2.05,;4.63,2.45,;2.75,.56,;3.65,-.69,;2.75,-1.93,;1.28,-1.46,;-.05,-2.23,;-1.39,-1.46,;-1.39,.08,;-.05,.85,;1.28,.08,;-2.72,.85,;-4.05,.08,;-5.39,.85,;-5.39,2.39,;-4.05,3.16,;-2.72,2.39,;-6.72,3.16,;-8.05,2.39,;-9.54,2.79,;-9.94,1.31,;-8.45,.91,;5.19,-.69,;5.96,.65,;7.5,.65,;8.27,1.98,;8.27,-.69,;9.78,-1.01,;9.94,-2.54,;8.53,-3.16,;7.5,-2.02,;5.96,-2.02,)| Show InChI InChI=1S/C26H32N6O/c1-15(2)23-24(18-10-16(3)26-27-14-28-32(26)11-18)31-22-9-8-21(30-25(22)23)17-4-6-19(7-5-17)29-20-12-33-13-20/h8-11,14-15,17,19-20,29,31H,4-7,12-13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427846
(US10544143, Example 279 | US10544143, Example 284 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)NC1COC1)-c1cc(C)c2ncnn2c1 |(2.06,3.14,;3.15,2.05,;4.63,2.45,;2.75,.56,;3.65,-.69,;2.75,-1.93,;1.28,-1.46,;-.05,-2.23,;-1.39,-1.46,;-1.39,.08,;-.05,.85,;1.28,.08,;-2.72,.85,;-4.05,.08,;-5.39,.85,;-5.39,2.39,;-4.05,3.16,;-2.72,2.39,;-6.72,3.16,;-8.05,2.39,;-9.54,2.79,;-9.94,1.31,;-8.45,.91,;5.19,-.69,;5.96,.65,;7.5,.65,;8.27,1.98,;8.27,-.69,;9.78,-1.01,;9.94,-2.54,;8.53,-3.16,;7.5,-2.02,;5.96,-2.02,)| Show InChI InChI=1S/C26H32N6O/c1-15(2)23-24(18-10-16(3)26-27-14-28-32(26)11-18)31-22-9-8-21(30-25(22)23)17-4-6-19(7-5-17)29-20-12-33-13-20/h8-11,14-15,17,19-20,29,31H,4-7,12-13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427846
(US10544143, Example 279 | US10544143, Example 284 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)NC1COC1)-c1cc(C)c2ncnn2c1 |(2.06,3.14,;3.15,2.05,;4.63,2.45,;2.75,.56,;3.65,-.69,;2.75,-1.93,;1.28,-1.46,;-.05,-2.23,;-1.39,-1.46,;-1.39,.08,;-.05,.85,;1.28,.08,;-2.72,.85,;-4.05,.08,;-5.39,.85,;-5.39,2.39,;-4.05,3.16,;-2.72,2.39,;-6.72,3.16,;-8.05,2.39,;-9.54,2.79,;-9.94,1.31,;-8.45,.91,;5.19,-.69,;5.96,.65,;7.5,.65,;8.27,1.98,;8.27,-.69,;9.78,-1.01,;9.94,-2.54,;8.53,-3.16,;7.5,-2.02,;5.96,-2.02,)| Show InChI InChI=1S/C26H32N6O/c1-15(2)23-24(18-10-16(3)26-27-14-28-32(26)11-18)31-22-9-8-21(30-25(22)23)17-4-6-19(7-5-17)29-20-12-33-13-20/h8-11,14-15,17,19-20,29,31H,4-7,12-13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427846
(US10544143, Example 279 | US10544143, Example 284 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)NC1COC1)-c1cc(C)c2ncnn2c1 |(2.06,3.14,;3.15,2.05,;4.63,2.45,;2.75,.56,;3.65,-.69,;2.75,-1.93,;1.28,-1.46,;-.05,-2.23,;-1.39,-1.46,;-1.39,.08,;-.05,.85,;1.28,.08,;-2.72,.85,;-4.05,.08,;-5.39,.85,;-5.39,2.39,;-4.05,3.16,;-2.72,2.39,;-6.72,3.16,;-8.05,2.39,;-9.54,2.79,;-9.94,1.31,;-8.45,.91,;5.19,-.69,;5.96,.65,;7.5,.65,;8.27,1.98,;8.27,-.69,;9.78,-1.01,;9.94,-2.54,;8.53,-3.16,;7.5,-2.02,;5.96,-2.02,)| Show InChI InChI=1S/C26H32N6O/c1-15(2)23-24(18-10-16(3)26-27-14-28-32(26)11-18)31-22-9-8-21(30-25(22)23)17-4-6-19(7-5-17)29-20-12-33-13-20/h8-11,14-15,17,19-20,29,31H,4-7,12-13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427846
(US10544143, Example 279 | US10544143, Example 284 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)NC1COC1)-c1cc(C)c2ncnn2c1 |(2.06,3.14,;3.15,2.05,;4.63,2.45,;2.75,.56,;3.65,-.69,;2.75,-1.93,;1.28,-1.46,;-.05,-2.23,;-1.39,-1.46,;-1.39,.08,;-.05,.85,;1.28,.08,;-2.72,.85,;-4.05,.08,;-5.39,.85,;-5.39,2.39,;-4.05,3.16,;-2.72,2.39,;-6.72,3.16,;-8.05,2.39,;-9.54,2.79,;-9.94,1.31,;-8.45,.91,;5.19,-.69,;5.96,.65,;7.5,.65,;8.27,1.98,;8.27,-.69,;9.78,-1.01,;9.94,-2.54,;8.53,-3.16,;7.5,-2.02,;5.96,-2.02,)| Show InChI InChI=1S/C26H32N6O/c1-15(2)23-24(18-10-16(3)26-27-14-28-32(26)11-18)31-22-9-8-21(30-25(22)23)17-4-6-19(7-5-17)29-20-12-33-13-20/h8-11,14-15,17,19-20,29,31H,4-7,12-13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
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