Found 6 hits Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM427878' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427878
(US10544143, Example 312 | US10544143, Example 315 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)NCC1(C)COC1 |(9.54,1.98,;8,1.98,;7.23,.65,;5.69,.65,;4.92,-.69,;5.69,-2.02,;7.23,-2.02,;8.26,-3.16,;9.66,-2.54,;9.5,-1.01,;8,-.69,;3.38,-.69,;2.47,-1.93,;1.01,-1.46,;-.33,-2.23,;-1.66,-1.46,;-2.99,-2.23,;-1.66,.08,;-.33,.85,;1.01,.08,;2.47,.56,;2.87,2.05,;1.78,3.14,;4.36,2.45,;-2.99,.85,;-4.33,.08,;-5.66,.85,;-5.66,2.39,;-4.33,3.16,;-2.99,2.39,;-7,3.16,;-8.33,2.39,;-8.33,.85,;-9.66,1.62,;-7.24,-.23,;-8.33,-1.32,;-9.42,-.23,)| Show InChI InChI=1S/C29H38N6O2/c1-17(2)24-26(20-11-23(36-5)28-31-16-32-35(28)12-20)33-22-10-18(3)25(34-27(22)24)19-6-8-21(9-7-19)30-13-29(4)14-37-15-29/h10-12,16-17,19,21,30,33H,6-9,13-15H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427878
(US10544143, Example 312 | US10544143, Example 315 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)NCC1(C)COC1 |(9.54,1.98,;8,1.98,;7.23,.65,;5.69,.65,;4.92,-.69,;5.69,-2.02,;7.23,-2.02,;8.26,-3.16,;9.66,-2.54,;9.5,-1.01,;8,-.69,;3.38,-.69,;2.47,-1.93,;1.01,-1.46,;-.33,-2.23,;-1.66,-1.46,;-2.99,-2.23,;-1.66,.08,;-.33,.85,;1.01,.08,;2.47,.56,;2.87,2.05,;1.78,3.14,;4.36,2.45,;-2.99,.85,;-4.33,.08,;-5.66,.85,;-5.66,2.39,;-4.33,3.16,;-2.99,2.39,;-7,3.16,;-8.33,2.39,;-8.33,.85,;-9.66,1.62,;-7.24,-.23,;-8.33,-1.32,;-9.42,-.23,)| Show InChI InChI=1S/C29H38N6O2/c1-17(2)24-26(20-11-23(36-5)28-31-16-32-35(28)12-20)33-22-10-18(3)25(34-27(22)24)19-6-8-21(9-7-19)30-13-29(4)14-37-15-29/h10-12,16-17,19,21,30,33H,6-9,13-15H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427878
(US10544143, Example 312 | US10544143, Example 315 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)NCC1(C)COC1 |(9.54,1.98,;8,1.98,;7.23,.65,;5.69,.65,;4.92,-.69,;5.69,-2.02,;7.23,-2.02,;8.26,-3.16,;9.66,-2.54,;9.5,-1.01,;8,-.69,;3.38,-.69,;2.47,-1.93,;1.01,-1.46,;-.33,-2.23,;-1.66,-1.46,;-2.99,-2.23,;-1.66,.08,;-.33,.85,;1.01,.08,;2.47,.56,;2.87,2.05,;1.78,3.14,;4.36,2.45,;-2.99,.85,;-4.33,.08,;-5.66,.85,;-5.66,2.39,;-4.33,3.16,;-2.99,2.39,;-7,3.16,;-8.33,2.39,;-8.33,.85,;-9.66,1.62,;-7.24,-.23,;-8.33,-1.32,;-9.42,-.23,)| Show InChI InChI=1S/C29H38N6O2/c1-17(2)24-26(20-11-23(36-5)28-31-16-32-35(28)12-20)33-22-10-18(3)25(34-27(22)24)19-6-8-21(9-7-19)30-13-29(4)14-37-15-29/h10-12,16-17,19,21,30,33H,6-9,13-15H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427878
(US10544143, Example 312 | US10544143, Example 315 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)NCC1(C)COC1 |(9.54,1.98,;8,1.98,;7.23,.65,;5.69,.65,;4.92,-.69,;5.69,-2.02,;7.23,-2.02,;8.26,-3.16,;9.66,-2.54,;9.5,-1.01,;8,-.69,;3.38,-.69,;2.47,-1.93,;1.01,-1.46,;-.33,-2.23,;-1.66,-1.46,;-2.99,-2.23,;-1.66,.08,;-.33,.85,;1.01,.08,;2.47,.56,;2.87,2.05,;1.78,3.14,;4.36,2.45,;-2.99,.85,;-4.33,.08,;-5.66,.85,;-5.66,2.39,;-4.33,3.16,;-2.99,2.39,;-7,3.16,;-8.33,2.39,;-8.33,.85,;-9.66,1.62,;-7.24,-.23,;-8.33,-1.32,;-9.42,-.23,)| Show InChI InChI=1S/C29H38N6O2/c1-17(2)24-26(20-11-23(36-5)28-31-16-32-35(28)12-20)33-22-10-18(3)25(34-27(22)24)19-6-8-21(9-7-19)30-13-29(4)14-37-15-29/h10-12,16-17,19,21,30,33H,6-9,13-15H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427878
(US10544143, Example 312 | US10544143, Example 315 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)NCC1(C)COC1 |(9.54,1.98,;8,1.98,;7.23,.65,;5.69,.65,;4.92,-.69,;5.69,-2.02,;7.23,-2.02,;8.26,-3.16,;9.66,-2.54,;9.5,-1.01,;8,-.69,;3.38,-.69,;2.47,-1.93,;1.01,-1.46,;-.33,-2.23,;-1.66,-1.46,;-2.99,-2.23,;-1.66,.08,;-.33,.85,;1.01,.08,;2.47,.56,;2.87,2.05,;1.78,3.14,;4.36,2.45,;-2.99,.85,;-4.33,.08,;-5.66,.85,;-5.66,2.39,;-4.33,3.16,;-2.99,2.39,;-7,3.16,;-8.33,2.39,;-8.33,.85,;-9.66,1.62,;-7.24,-.23,;-8.33,-1.32,;-9.42,-.23,)| Show InChI InChI=1S/C29H38N6O2/c1-17(2)24-26(20-11-23(36-5)28-31-16-32-35(28)12-20)33-22-10-18(3)25(34-27(22)24)19-6-8-21(9-7-19)30-13-29(4)14-37-15-29/h10-12,16-17,19,21,30,33H,6-9,13-15H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427878
(US10544143, Example 312 | US10544143, Example 315 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)NCC1(C)COC1 |(9.54,1.98,;8,1.98,;7.23,.65,;5.69,.65,;4.92,-.69,;5.69,-2.02,;7.23,-2.02,;8.26,-3.16,;9.66,-2.54,;9.5,-1.01,;8,-.69,;3.38,-.69,;2.47,-1.93,;1.01,-1.46,;-.33,-2.23,;-1.66,-1.46,;-2.99,-2.23,;-1.66,.08,;-.33,.85,;1.01,.08,;2.47,.56,;2.87,2.05,;1.78,3.14,;4.36,2.45,;-2.99,.85,;-4.33,.08,;-5.66,.85,;-5.66,2.39,;-4.33,3.16,;-2.99,2.39,;-7,3.16,;-8.33,2.39,;-8.33,.85,;-9.66,1.62,;-7.24,-.23,;-8.33,-1.32,;-9.42,-.23,)| Show InChI InChI=1S/C29H38N6O2/c1-17(2)24-26(20-11-23(36-5)28-31-16-32-35(28)12-20)33-22-10-18(3)25(34-27(22)24)19-6-8-21(9-7-19)30-13-29(4)14-37-15-29/h10-12,16-17,19,21,30,33H,6-9,13-15H2,1-5H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this Ligand-Target Pair | |