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Found 1 hit Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM450114'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))		BDBM450114
PNG
(US10703755, Example 295)
Show SMILES COc1nc(C)c2nc(-c3cncc(c3)C#N)n(Cc3ccc(OC4CC5CCC(C4)N5C)cc3F)c2n1
Show InChI InChI=1S/C28H28FN7O2/c1-16-25-27(34-28(32-16)37-3)36(26(33-25)19-8-17(12-30)13-31-14-19)15-18-4-7-22(11-24(18)29)38-23-9-20-5-6-21(10-23)35(20)2/h4,7-8,11,13-14,20-21,23H,5-6,9-10,15H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter™ HEK293 cell), which is human emb...

US Patent US10703755 (2020)


BindingDB Entry DOI: 10.7270/Q28W3HBW
More data for this
Ligand-Target Pair