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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM50514134'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))		BDBM50514134
PNG
(CHEMBL4435177)
Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(Oc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H12ClF4NO2/c21-16-5-2-6-17(22)18(16)19(27)26-13-7-9-14(10-8-13)28-15-4-1-3-12(11-15)20(23,24)25/h1-11H,(H,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.65E+3n/an/an/an/an/an/a



University of Colorado Boulder

Curated by ChEMBL


Assay Description
Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...

J Med Chem 62: 10221-10244 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01201
BindingDB Entry DOI: 10.7270/Q2BP064W
More data for this
Ligand-Target Pair