Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM50543486'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50543486 (CHEMBL4649560) Show SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(C)c2c1)-c1ccc(OC)cc1OC Show InChI InChI=1S/C25H33N3O2/c1-17-22-15-19(18-9-12-28(13-10-18)14-11-26-2)5-8-23(22)27-25(17)21-7-6-20(29-3)16-24(21)30-4/h5-8,15-16,18,26-27H,9-14H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincub...				ACS Med Chem Lett 11: 1751-1758 (2020) Article DOI: 10.1021/acsmedchemlett.0c00264 BindingDB Entry DOI: 10.7270/Q22N55TH
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