Found 6 hits Enz. Inhib. hit(s) with Target = 'Toll-like receptor 8' and Ligand = 'BDBM427822' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427822
(US10544143, Example 255 | US10544143, Example 256 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC2(C1)CS(=O)(=O)C2)-c1cn(C)c2ncccc12 |(3.6,1.96,;4.69,.87,;6.17,1.27,;4.29,-.62,;5.19,-1.87,;4.29,-3.11,;2.82,-2.64,;1.49,-3.41,;.16,-2.64,;.16,-1.1,;1.49,-.33,;2.82,-1.1,;-1.18,-.33,;-2.51,-1.1,;-3.84,-.33,;-3.84,1.21,;-2.51,1.98,;-1.18,1.21,;-5.18,1.98,;-5.58,3.47,;-7.06,3.07,;-6.67,1.58,;-7.46,4.56,;-8.95,4.16,;-9.35,5.65,;-10.44,3.76,;-8.55,2.67,;6.73,-1.87,;7.64,-.62,;9.1,-1.1,;10.44,-.33,;9.1,-2.64,;10.25,-3.67,;9.93,-5.17,;8.46,-5.65,;7.32,-4.62,;7.64,-3.11,)| Show InChI InChI=1S/C29H35N5O2S/c1-18(2)25-26(22-13-33(3)28-21(22)5-4-12-30-28)32-24-11-10-23(31-27(24)25)19-6-8-20(9-7-19)34-14-29(15-34)16-37(35,36)17-29/h4-5,10-13,18-20,32H,6-9,14-17H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427822
(US10544143, Example 255 | US10544143, Example 256 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC2(C1)CS(=O)(=O)C2)-c1cn(C)c2ncccc12 |(3.6,1.96,;4.69,.87,;6.17,1.27,;4.29,-.62,;5.19,-1.87,;4.29,-3.11,;2.82,-2.64,;1.49,-3.41,;.16,-2.64,;.16,-1.1,;1.49,-.33,;2.82,-1.1,;-1.18,-.33,;-2.51,-1.1,;-3.84,-.33,;-3.84,1.21,;-2.51,1.98,;-1.18,1.21,;-5.18,1.98,;-5.58,3.47,;-7.06,3.07,;-6.67,1.58,;-7.46,4.56,;-8.95,4.16,;-9.35,5.65,;-10.44,3.76,;-8.55,2.67,;6.73,-1.87,;7.64,-.62,;9.1,-1.1,;10.44,-.33,;9.1,-2.64,;10.25,-3.67,;9.93,-5.17,;8.46,-5.65,;7.32,-4.62,;7.64,-3.11,)| Show InChI InChI=1S/C29H35N5O2S/c1-18(2)25-26(22-13-33(3)28-21(22)5-4-12-30-28)32-24-11-10-23(31-27(24)25)19-6-8-20(9-7-19)34-14-29(15-34)16-37(35,36)17-29/h4-5,10-13,18-20,32H,6-9,14-17H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427822
(US10544143, Example 255 | US10544143, Example 256 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC2(C1)CS(=O)(=O)C2)-c1cn(C)c2ncccc12 |(3.6,1.96,;4.69,.87,;6.17,1.27,;4.29,-.62,;5.19,-1.87,;4.29,-3.11,;2.82,-2.64,;1.49,-3.41,;.16,-2.64,;.16,-1.1,;1.49,-.33,;2.82,-1.1,;-1.18,-.33,;-2.51,-1.1,;-3.84,-.33,;-3.84,1.21,;-2.51,1.98,;-1.18,1.21,;-5.18,1.98,;-5.58,3.47,;-7.06,3.07,;-6.67,1.58,;-7.46,4.56,;-8.95,4.16,;-9.35,5.65,;-10.44,3.76,;-8.55,2.67,;6.73,-1.87,;7.64,-.62,;9.1,-1.1,;10.44,-.33,;9.1,-2.64,;10.25,-3.67,;9.93,-5.17,;8.46,-5.65,;7.32,-4.62,;7.64,-3.11,)| Show InChI InChI=1S/C29H35N5O2S/c1-18(2)25-26(22-13-33(3)28-21(22)5-4-12-30-28)32-24-11-10-23(31-27(24)25)19-6-8-20(9-7-19)34-14-29(15-34)16-37(35,36)17-29/h4-5,10-13,18-20,32H,6-9,14-17H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427822
(US10544143, Example 255 | US10544143, Example 256 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC2(C1)CS(=O)(=O)C2)-c1cn(C)c2ncccc12 |(3.6,1.96,;4.69,.87,;6.17,1.27,;4.29,-.62,;5.19,-1.87,;4.29,-3.11,;2.82,-2.64,;1.49,-3.41,;.16,-2.64,;.16,-1.1,;1.49,-.33,;2.82,-1.1,;-1.18,-.33,;-2.51,-1.1,;-3.84,-.33,;-3.84,1.21,;-2.51,1.98,;-1.18,1.21,;-5.18,1.98,;-5.58,3.47,;-7.06,3.07,;-6.67,1.58,;-7.46,4.56,;-8.95,4.16,;-9.35,5.65,;-10.44,3.76,;-8.55,2.67,;6.73,-1.87,;7.64,-.62,;9.1,-1.1,;10.44,-.33,;9.1,-2.64,;10.25,-3.67,;9.93,-5.17,;8.46,-5.65,;7.32,-4.62,;7.64,-3.11,)| Show InChI InChI=1S/C29H35N5O2S/c1-18(2)25-26(22-13-33(3)28-21(22)5-4-12-30-28)32-24-11-10-23(31-27(24)25)19-6-8-20(9-7-19)34-14-29(15-34)16-37(35,36)17-29/h4-5,10-13,18-20,32H,6-9,14-17H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427822
(US10544143, Example 255 | US10544143, Example 256 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC2(C1)CS(=O)(=O)C2)-c1cn(C)c2ncccc12 |(3.6,1.96,;4.69,.87,;6.17,1.27,;4.29,-.62,;5.19,-1.87,;4.29,-3.11,;2.82,-2.64,;1.49,-3.41,;.16,-2.64,;.16,-1.1,;1.49,-.33,;2.82,-1.1,;-1.18,-.33,;-2.51,-1.1,;-3.84,-.33,;-3.84,1.21,;-2.51,1.98,;-1.18,1.21,;-5.18,1.98,;-5.58,3.47,;-7.06,3.07,;-6.67,1.58,;-7.46,4.56,;-8.95,4.16,;-9.35,5.65,;-10.44,3.76,;-8.55,2.67,;6.73,-1.87,;7.64,-.62,;9.1,-1.1,;10.44,-.33,;9.1,-2.64,;10.25,-3.67,;9.93,-5.17,;8.46,-5.65,;7.32,-4.62,;7.64,-3.11,)| Show InChI InChI=1S/C29H35N5O2S/c1-18(2)25-26(22-13-33(3)28-21(22)5-4-12-30-28)32-24-11-10-23(31-27(24)25)19-6-8-20(9-7-19)34-14-29(15-34)16-37(35,36)17-29/h4-5,10-13,18-20,32H,6-9,14-17H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427822
(US10544143, Example 255 | US10544143, Example 256 ...)Show SMILES CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC2(C1)CS(=O)(=O)C2)-c1cn(C)c2ncccc12 |(3.6,1.96,;4.69,.87,;6.17,1.27,;4.29,-.62,;5.19,-1.87,;4.29,-3.11,;2.82,-2.64,;1.49,-3.41,;.16,-2.64,;.16,-1.1,;1.49,-.33,;2.82,-1.1,;-1.18,-.33,;-2.51,-1.1,;-3.84,-.33,;-3.84,1.21,;-2.51,1.98,;-1.18,1.21,;-5.18,1.98,;-5.58,3.47,;-7.06,3.07,;-6.67,1.58,;-7.46,4.56,;-8.95,4.16,;-9.35,5.65,;-10.44,3.76,;-8.55,2.67,;6.73,-1.87,;7.64,-.62,;9.1,-1.1,;10.44,-.33,;9.1,-2.64,;10.25,-3.67,;9.93,-5.17,;8.46,-5.65,;7.32,-4.62,;7.64,-3.11,)| Show InChI InChI=1S/C29H35N5O2S/c1-18(2)25-26(22-13-33(3)28-21(22)5-4-12-30-28)32-24-11-10-23(31-27(24)25)19-6-8-20(9-7-19)34-14-29(15-34)16-37(35,36)17-29/h4-5,10-13,18-20,32H,6-9,14-17H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
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