BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Trace amine-associated receptor 1' and Ligand = 'BDBM50359499'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Trace amine-associated receptor 1 (Homo sapiens (Human))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay				Bioorg Med Chem 19: 7044-8 (2011) Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Trace amine-associated receptor 1 (Macaca mulatta)	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader				Bioorg Med Chem 19: 7044-8 (2011) Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Trace amine-associated receptor 1 (Rattus norvegicus (Rat))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	890	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting				Bioorg Med Chem 19: 7044-8 (2011) Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Mus musculus (Mouse))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	920	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting				Bioorg Med Chem 19: 7044-8 (2011) Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Mus musculus (Mouse))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 mins				Bioorg Med Chem 19: 7044-8 (2011) Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Rattus norvegicus (Rat))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.04E+3	n/a	n/a	n/a	n/a
Oregon Health & Science University Curated by ChEMBL					Assay Description Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...				J Med Chem 57: 378-90 (2014) Article DOI: 10.1021/jm401316v BindingDB Entry DOI: 10.7270/Q2BC42HK
Oregon Health & Science University Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Rattus norvegicus (Rat))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	202	n/a	n/a	n/a	n/a
Oregon Health & Science University Curated by ChEMBL					Assay Description Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...				J Med Chem 57: 378-90 (2014) Article DOI: 10.1021/jm401316v BindingDB Entry DOI: 10.7270/Q2BC42HK
Oregon Health & Science University Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Mus musculus (Mouse))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Oregon Health & Science University Curated by ChEMBL					Assay Description Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...				J Med Chem 57: 378-90 (2014) Article DOI: 10.1021/jm401316v BindingDB Entry DOI: 10.7270/Q2BC42HK
Oregon Health & Science University Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Mus musculus (Mouse))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	279	n/a	n/a	n/a	n/a
Oregon Health & Science University Curated by ChEMBL					Assay Description Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay				J Med Chem 57: 378-90 (2014) Article DOI: 10.1021/jm401316v BindingDB Entry DOI: 10.7270/Q2BC42HK
Oregon Health & Science University Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Rattus norvegicus (Rat))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	133	n/a	n/a	n/a	n/a
Oregon Health & Science University Curated by ChEMBL					Assay Description Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay				J Med Chem 57: 378-90 (2014) Article DOI: 10.1021/jm401316v BindingDB Entry DOI: 10.7270/Q2BC42HK
Oregon Health & Science University Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Mus musculus (Mouse))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.82E+3	n/a	n/a	n/a	n/a
Oregon Health & Science University Curated by ChEMBL					Assay Description Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...				J Med Chem 57: 378-90 (2014) Article DOI: 10.1021/jm401316v BindingDB Entry DOI: 10.7270/Q2BC42HK
Oregon Health & Science University Curated by ChEMBL					More data for this Ligand-Target Pair
Trace amine-associated receptor 1 (Homo sapiens (Human))	BDBM50359499 ((S)Methamphetamine \| METHAMPHETAMINE) Show SMILES CN[C@@H](C)Cc1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay				Bioorg Med Chem 19: 7044-8 (2011) Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)