BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50133817'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (Mus musculus)	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
University of Shizuoka Curated by ChEMBL					Assay Description Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellul...				J Nat Prod 77: 285-97 (2014) Article DOI: 10.1021/np400885u BindingDB Entry DOI: 10.7270/Q20P11H1
University of Shizuoka Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Mus musculus)	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Shizuoka Curated by ChEMBL					Assay Description Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...				J. Nat. Prod. 77: 1831-8 (2014) Article DOI: 10.1021/np500235b BindingDB Entry DOI: 10.7270/Q27S7QDF
University of Shizuoka Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Mus musculus)	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Shizuoka Curated by ChEMBL					Assay Description Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...				J. Nat. Prod. 77: 1831-8 (2014) Article DOI: 10.1021/np500235b BindingDB Entry DOI: 10.7270/Q27S7QDF
University of Shizuoka Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Mus musculus)	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Shizuoka Curated by ChEMBL					Assay Description Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellula...				J Nat Prod 77: 285-97 (2014) Article DOI: 10.1021/np400885u BindingDB Entry DOI: 10.7270/Q20P11H1
University of Shizuoka Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat))	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	475	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol mediated current amplitude at +80 mV holding potential b...				J Med Chem 59: 2179-91 (2016) Article DOI: 10.1021/acs.jmedchem.5b01914 BindingDB Entry DOI: 10.7270/Q2B85B1Z
University of Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	475	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at TRPM8 (unknown origin) assessed as reduction in menthol-induced calcium influx				J Med Chem 61: 6140-6152 (2018) Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3
University of Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50133817 (4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Inhibition of TRPM8 (unknown origin)				Bioorg Med Chem 21: 6542-53 (2013) Article DOI: 10.1016/j.bmc.2013.08.031 BindingDB Entry DOI: 10.7270/Q2TH8P5S
Glenmark Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair