BindingDB PrimarySearch

Found 6 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50241426'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat))	BDBM50241426 (3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
National Research Council Curated by ChEMBL					Assay Description Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...				Bioorg Med Chem Lett 25: 2285-90 (2015) Article DOI: 10.1016/j.bmcl.2015.04.032 BindingDB Entry DOI: 10.7270/Q2QZ2CP2
National Research Council Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50241426 (3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50241426 (3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay				Bioorg Med Chem Lett 23: 6118-22 (2013) Article DOI: 10.1016/j.bmcl.2013.09.016 BindingDB Entry DOI: 10.7270/Q2125V4N
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50241426 (3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Ferrara University Curated by ChEMBL					Assay Description Activation of TRPM8 channel				J Med Chem 53: 5085-107 (2010) Article DOI: 10.1021/jm100062h BindingDB Entry DOI: 10.7270/Q2416Z02
Ferrara University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat))	BDBM50241426 (3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
National Research Council Curated by ChEMBL					Assay Description Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry				Bioorg Med Chem Lett 25: 2285-90 (2015) Article DOI: 10.1016/j.bmcl.2015.04.032 BindingDB Entry DOI: 10.7270/Q2QZ2CP2
National Research Council Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat))	BDBM50241426 (3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
Università di Milano Curated by ChEMBL					Assay Description Agonist activity at rat recombinant TRPM8 receptor expressed in HEK293 cells assessed as increase in intracellular calcium concentration by fluorimet...				Bioorg Med Chem 17: 1636-9 (2009) Article DOI: 10.1016/j.bmc.2008.12.057 BindingDB Entry DOI: 10.7270/Q28915RH
Università di Milano Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)