BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50331285'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50331285 (2-(5-(benzyloxy)-2-methyl-1H-indol-3-yl)ethanamine...) Show SMILES Cc1[nH]c2ccc(OCc3ccccc3)cc2c1CCN Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Renovis, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 m...				Bioorg Med Chem Lett 20: 7076-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.099 BindingDB Entry DOI: 10.7270/Q2DN459H
Renovis, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50331285 (2-(5-(benzyloxy)-2-methyl-1H-indol-3-yl)ethanamine...) Show SMILES Cc1[nH]c2ccc(OCc3ccccc3)cc2c1CCN Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
Renovis, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mi...				Bioorg Med Chem Lett 20: 7076-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.099 BindingDB Entry DOI: 10.7270/Q2DN459H
Renovis, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair