BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50463856'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM50463856
PNG
(CHEMBL4247395)
Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccccc1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C21H13F7N2O/c22-16-11-13(8-9-14(16)20(23,24)25)17(30-19(31)12-5-2-1-3-6-12)18-15(21(26,27)28)7-4-10-29-18/h1-11,17H,(H,30,31)/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...


J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)
BDBM50463856
PNG
(CHEMBL4247395)
Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccccc1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C21H13F7N2O/c22-16-11-13(8-9-14(16)20(23,24)25)17(30-19(31)12-5-2-1-3-6-12)18-15(21(26,27)28)7-4-10-29-18/h1-11,17H,(H,30,31)/t17-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...


J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair