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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50465616'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Rattus norvegicus (Rat))		BDBM50465616
PNG
(CHEMBL4284391)
Show SMILES C(Cc1c[nH]c2ccccc12)N1Cc2cccc3cccc(C1)c23
Show InChI InChI=1S/C22H20N2/c1-2-10-21-20(9-1)17(13-23-21)11-12-24-14-18-7-3-5-16-6-4-8-19(15-24)22(16)18/h1-10,13,23H,11-12,14-15H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.18E+4n/an/an/an/an/an/a



University of Salerno

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...

J Med Chem 61: 6140-6152 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00545
BindingDB Entry DOI: 10.7270/Q2FN18V3
More data for this
Ligand-Target Pair