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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50465617'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Rattus norvegicus (Rat))		BDBM50465617
PNG
(CHEMBL4280979)
Show SMILES OC(=O)c1ccc(CN2CCc3c([nH]c4ccccc34)C2c2ccccc2)cc1
Show InChI InChI=1S/C25H22N2O2/c28-25(29)19-12-10-17(11-13-19)16-27-15-14-21-20-8-4-5-9-22(20)26-23(21)24(27)18-6-2-1-3-7-18/h1-13,24,26H,14-16H2,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Salerno

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...

J Med Chem 61: 6140-6152 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00545
BindingDB Entry DOI: 10.7270/Q2FN18V3
More data for this
Ligand-Target Pair