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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50544519'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Rattus norvegicus (Rat))		BDBM50544519
PNG
(CHEMBL4640958)
Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@@H](CC(C)C)N1C(=O)N(Cc1ccc(OC)cc1)C2=O |r|
Show InChI InChI=1S/C25H27N3O3/c1-15(2)12-21-23-19(18-6-4-5-7-20(18)26-23)13-22-24(29)27(25(30)28(21)22)14-16-8-10-17(31-3)11-9-16/h4-11,15,21-22,26H,12-14H2,1-3H3/t21-,22+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



University of Salerno

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...

J Med Chem 63: 9672-9694 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00816
BindingDB Entry DOI: 10.7270/Q2GF0Z2X
More data for this
Ligand-Target Pair