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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50544533'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Rattus norvegicus (Rat))		BDBM50544533
PNG
(CHEMBL4635623)
Show SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@@H](N1C(=O)N(C2=O)c1ccccc1F)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C25H17F2N3O2/c26-15-11-9-14(10-12-15)23-22-17(16-5-1-3-7-19(16)28-22)13-21-24(31)30(25(32)29(21)23)20-8-4-2-6-18(20)27/h1-12,21,23,28H,13H2/t21-,23+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



University of Salerno

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...

J Med Chem 63: 9672-9694 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00816
BindingDB Entry DOI: 10.7270/Q2GF0Z2X
More data for this
Ligand-Target Pair