BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 4' and Ligand = 'BDBM50525943'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50525943
PNG
(CHEMBL4449850)
Show SMILES COc1ccc(cc1)-n1c(nc2cc(F)ccc2c1=O)N1CCN(C)CC1
Show InChI InChI=1S/C20H21FN4O2/c1-23-9-11-24(12-10-23)20-22-18-13-14(21)3-8-17(18)19(26)25(20)15-4-6-16(27-2)7-5-15/h3-8,13H,9-12H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.70E+3n/an/an/an/a



Asahi Kasei Medical Corporation

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium level after 30 mins by Fura-2 AM/...

J Med Chem 62: 1468-1483 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01615
BindingDB Entry DOI: 10.7270/Q2HD803S
More data for this
Ligand-Target Pair