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Found 1 hit Enz. Inhib. hit(s) with Target = 'Transmembrane domain-containing protein TMIGD3' and Ligand = 'BDBM50236794'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transmembrane domain-containing protein TMIGD3


(Homo sapiens (Human))		BDBM50236794
PNG
(CHEMBL4081828)
Show SMILES [H][C@]12C[C@]1([C@@H](O)[C@@H](O)[C@@H]2n1cnc2c(NC)nc(nc12)C#Cc1ccc(Cl)s1)C(=O)NCCN |r|
Show InChI InChI=1S/C21H22ClN7O3S/c1-24-18-14-19(28-13(27-18)5-3-10-2-4-12(22)33-10)29(9-26-14)15-11-8-21(11,17(31)16(15)30)20(32)25-7-6-23/h2,4,9,11,15-17,30-31H,6-8,23H2,1H3,(H,25,32)(H,24,27,28)/t11-,15-,16+,17+,21+/m1/s1
UniProtKB/SwissProt

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Similars
Article
PubMed
 156n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of ICAM-1 to LFA-1 (Leukocyte function-associated antigen-1), evaluated ELISA

J Med Chem 60: 3109-3123 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00141
BindingDB Entry DOI: 10.7270/Q2Z60RBZ
More data for this
Ligand-Target Pair