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Found 1 hit Enz. Inhib. hit(s) with Target = 'Trypsin' and Ligand = 'BDBM50459515'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Trypsin


(Homo sapiens (Human))		BDBM50459515
PNG
(CHEMBL4216138)
Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2cnccc12)-c1ccccc1
Show InChI InChI=1S/C23H23N5O3/c1-14-19(18-9-10-24-12-20(18)25-14)11-22(30)31-13-21(29)26-23-15(2)27-28(16(23)3)17-7-5-4-6-8-17/h4-10,12,25H,11,13H2,1-3H3,(H,26,29)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 330n/an/an/an/an/an/a



German Cancer Research Center (DKFZ)

Curated by ChEMBL


Assay Description
Inhibition of trypsin (unknown origin) pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 mins

J Med Chem 61: 8859-8874 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01106
BindingDB Entry DOI: 10.7270/Q279479B
More data for this
Ligand-Target Pair