Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 2' and Ligand = 'BDBM357745'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357745 (KM-05-125/(I-13) | US10214530, Example 13) Show SMILES COc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1 Show InChI InChI=1S/C24H22N6O3/c1-33-16-9-10-17-18(11-16)26-19(25-17)12-20-27-22-21(29(20)13-14-5-3-2-4-6-14)23(31)28-24(32)30(22)15-7-8-15/h2-6,9-11,15H,7-8,12-13H2,1H3,(H,25,26)(H,28,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00598 BindingDB Entry DOI: 10.7270/Q2G164VF
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Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357745 (KM-05-125/(I-13) | US10214530, Example 13) Show SMILES COc1ccc2nc(Cc3nc4n(C5CC5)c(=O)[nH]c(=O)c4n3Cc3ccccc3)[nH]c2c1 Show InChI InChI=1S/C24H22N6O3/c1-33-16-9-10-17-18(11-16)26-19(25-17)12-20-27-22-21(29(20)13-14-5-3-2-4-6-14)23(31)28-24(32)30(22)15-7-8-15/h2-6,9-11,15H,7-8,12-13H2,1H3,(H,25,26)(H,28,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent					Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...				US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK
					More data for this Ligand-Target Pair