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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 2' and Ligand = 'BDBM357754'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357754
PNG
(KM-05-60/(I-10) | US10214530, Example 10)
Show SMILES Cn1c2nc(Cc3nc4cc(NC(=O)CC[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O |r|
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KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 170n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00598
BindingDB Entry DOI: 10.7270/Q2G164VF
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 2


(Homo sapiens (Human))
BDBM357754
PNG
(KM-05-60/(I-10) | US10214530, Example 10)
Show SMILES Cn1c2nc(Cc3nc4cc(NC(=O)CC[C@H](N)C(O)=O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

US Patent


Assay Description
These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...


US Patent US10214530 (2019)


BindingDB Entry DOI: 10.7270/Q25B04SK
More data for this
Ligand-Target Pair