Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 2' and Ligand = 'BDBM357776'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357776 (KM483/(I-42) | US10214530, Example 48) Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccc(cc3)N3CCOCC3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H23N7O3S/c1-29-20-19(21(32)28-23(29)33)31(14-15-6-8-16(9-7-15)30-10-12-34-13-11-30)24(27-20)35-22-25-17-4-2-3-5-18(17)26-22/h2-9H,10-14H2,1H3,(H,25,26)(H,28,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00598 BindingDB Entry DOI: 10.7270/Q2G164VF
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Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357776 (KM483/(I-42) | US10214530, Example 48) Show SMILES Cn1c2nc(Sc3nc4ccccc4[nH]3)n(Cc3ccc(cc3)N3CCOCC3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H23N7O3S/c1-29-20-19(21(32)28-23(29)33)31(14-15-6-8-16(9-7-15)30-10-12-34-13-11-30)24(27-20)35-22-25-17-4-2-3-5-18(17)26-22/h2-9H,10-14H2,1H3,(H,25,26)(H,28,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent					Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...				US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK
					More data for this Ligand-Target Pair