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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tumor necrosis factor' and Ligand = 'BDBM50454023'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tumor necrosis factor


(Mus musculus)		BDBM50454023
PNG
(CHEMBL4215786)
Show SMILES CCCCn1cnc(CC(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)c1Cl
Show InChI InChI=1S/C27H23ClN2O6/c1-2-3-12-30-14-29-18(25(30)28)13-17(21-23(31)15-8-4-6-10-19(15)35-26(21)33)22-24(32)16-9-5-7-11-20(16)36-27(22)34/h4-11,14,17,31-32H,2-3,12-13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.65E+4n/an/an/an/an/an/a



Padmashri Vikhe Patil College of Arts

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant TNF-alpha binding to antibody preincubated for 30 mins followed by antibody addition measured after 2 hrs by ELISA

Bioorg Med Chem Lett 28: 24-30 (2018)


Article DOI: 10.1016/j.bmcl.2017.11.026
BindingDB Entry DOI: 10.7270/Q2TQ6441
More data for this
Ligand-Target Pair