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Found 1 hit Enz. Inhib. hit(s) with Target = 'Type-1 angiotensin II receptor' and Ligand = 'BDBM50043456'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Type-1 angiotensin II receptor


(RABBIT)		BDBM50043456
PNG
(CHEMBL337217 | [4-(2-Ethyl-5,7-dimethyl-imidazo[4,...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)N(C)C(c1nnn[nH]1)c1ccccc1
Show InChI InChI=1S/C26H28N8/c1-5-22-28-23-17(2)15-18(3)27-26(23)34(22)16-19-11-13-21(14-12-19)33(4)24(25-29-31-32-30-25)20-9-7-6-8-10-20/h6-15,24H,5,16H2,1-4H3,(H,29,30,31,32)
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n/an/a 15n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.

J Med Chem 36: 4239-49 (1994)


BindingDB Entry DOI: 10.7270/Q22V2F6P
More data for this
Ligand-Target Pair