Found 3 hits Enz. Inhib. hit(s) with Target = 'Type-1 angiotensin II receptor' and Ligand = 'BDBM50159152' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50159152
(CHEMBL3786986)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN\C(N)=N\C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C57H85N15O15.4C2HF3O2/c1-5-34(4)47(53(81)67-42(29-37-31-61-32-64-37)54(82)72-22-10-14-44(72)51(79)68-43(55(83)84)28-35-11-7-6-8-12-35)70-50(78)41(27-36-15-17-38(73)18-16-36)66-52(80)46(33(2)3)69-49(77)40(65-48(76)39(59)30-45(74)75)13-9-20-62-56(60)71-57(85)63-21-24-87-26-25-86-23-19-58;4*3-2(4,5)1(6)7/h6-8,11-12,15-18,31-34,39-44,46-47,73H,5,9-10,13-14,19-30,58-59H2,1-4H3,(H,61,64)(H,65,76)(H,66,80)(H,67,81)(H,68,79)(H,69,77)(H,70,78)(H,74,75)(H,83,84)(H4,60,62,63,71,85);4*(H,6,7)/t34-,39-,40-,41-,42-,43-,44-,46-,47-;;;;/m0..../s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re... |
J Med Chem 59: 1925-45 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01495 BindingDB Entry DOI: 10.7270/Q2V69MGK |
More data for this Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50159152
(CHEMBL3786986)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN\C(N)=N\C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C57H85N15O15.4C2HF3O2/c1-5-34(4)47(53(81)67-42(29-37-31-61-32-64-37)54(82)72-22-10-14-44(72)51(79)68-43(55(83)84)28-35-11-7-6-8-12-35)70-50(78)41(27-36-15-17-38(73)18-16-36)66-52(80)46(33(2)3)69-49(77)40(65-48(76)39(59)30-45(74)75)13-9-20-62-56(60)71-57(85)63-21-24-87-26-25-86-23-19-58;4*3-2(4,5)1(6)7/h6-8,11-12,15-18,31-34,39-44,46-47,73H,5,9-10,13-14,19-30,58-59H2,1-4H3,(H,61,64)(H,65,76)(H,66,80)(H,67,81)(H,68,79)(H,69,77)(H,70,78)(H,74,75)(H,83,84)(H4,60,62,63,71,85);4*(H,6,7)/t34-,39-,40-,41-,42-,43-,44-,46-,47-;;;;/m0..../s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization... |
J Med Chem 59: 1925-45 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01495 BindingDB Entry DOI: 10.7270/Q2V69MGK |
More data for this Ligand-Target Pair | |
Type-1 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50159152
(CHEMBL3786986)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN\C(N)=N\C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C57H85N15O15.4C2HF3O2/c1-5-34(4)47(53(81)67-42(29-37-31-61-32-64-37)54(82)72-22-10-14-44(72)51(79)68-43(55(83)84)28-35-11-7-6-8-12-35)70-50(78)41(27-36-15-17-38(73)18-16-36)66-52(80)46(33(2)3)69-49(77)40(65-48(76)39(59)30-45(74)75)13-9-20-62-56(60)71-57(85)63-21-24-87-26-25-86-23-19-58;4*3-2(4,5)1(6)7/h6-8,11-12,15-18,31-34,39-44,46-47,73H,5,9-10,13-14,19-30,58-59H2,1-4H3,(H,61,64)(H,65,76)(H,66,80)(H,67,81)(H,68,79)(H,69,77)(H,70,78)(H,74,75)(H,83,84)(H4,60,62,63,71,85);4*(H,6,7)/t34-,39-,40-,41-,42-,43-,44-,46-,47-;;;;/m0..../s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization... |
J Med Chem 59: 1925-45 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01495 BindingDB Entry DOI: 10.7270/Q2V69MGK |
More data for this Ligand-Target Pair | |