Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13530![]() (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13530![]() (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13530![]() (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB PCBioAssay | n/a | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |