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Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ABL1 [64-515]' and Ligand = 'BDBM477774'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase ABL1 [64-515]


(Homo sapiens (Human))		BDBM477774
PNG
(US10889571, Example 118 | US20240101536, Example 1...)
Show SMILES Cn1c(nc2cc(cc(-c3cncnc3)c12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1)C(F)F
Show InChI InChI=1S/C21H14ClF4N5O2/c1-31-17-15(12-8-27-10-28-9-12)6-11(7-16(17)30-19(31)18(23)24)20(32)29-13-2-4-14(5-3-13)33-21(22,25)26/h2-10,18H,1H3,(H,29,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 0.340n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1 [64-515]


(Homo sapiens (Human))		BDBM477774
PNG
(US10889571, Example 118 | US20240101536, Example 1...)
Show SMILES Cn1c(nc2cc(cc(-c3cncnc3)c12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1)C(F)F
Show InChI InChI=1S/C21H14ClF4N5O2/c1-31-17-15(12-8-27-10-28-9-12)6-11(7-16(17)30-19(31)18(23)24)20(32)29-13-2-4-14(5-3-13)33-21(22,25)26/h2-10,18H,1H3,(H,29,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.340n/an/an/an/an/an/a



Terns, Inc.

US Patent


Assay Description
ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...

US Patent US10889571 (2021)


BindingDB Entry DOI: 10.7270/Q27S7RW4
More data for this
Ligand-Target Pair