Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM230118' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM230118
(US10106559, Example 47 | US10435415, Example 47 | ...)Show SMILES CC(C)(O)c1ccc2c(c1)[nH]c1c(cc(Cl)c(-c3cccc(c3Cl)-n3c(=O)[nH]c4c(F)cccc4c3=O)c21)C(N)=O |(-8.37,.74,;-7.03,1.51,;-6.64,.02,;-7.8,2.85,;-5.49,1.51,;-4.59,.27,;-3.06,.43,;-2.43,1.83,;-3.34,3.08,;-4.87,2.92,;-2.43,4.33,;-.97,3.85,;.37,4.62,;1.7,3.85,;1.7,2.31,;3.03,1.54,;.37,1.54,;.37,,;-.97,-.77,;-.97,-2.31,;.37,-3.08,;1.7,-2.31,;1.7,-.77,;3.03,,;3.03,-3.08,;3.03,-4.62,;1.7,-5.39,;4.37,-5.39,;5.7,-4.62,;7.03,-5.39,;7.03,-6.93,;8.37,-4.62,;8.37,-3.08,;7.03,-2.31,;5.7,-3.08,;4.37,-2.31,;4.37,-.77,;-.97,2.31,;.37,6.16,;1.7,6.93,;-.97,6.93,)| Show InChI InChI=1S/C30H21Cl2FN4O4/c1-30(2,41)13-9-10-14-20(11-13)35-26-17(27(34)38)12-18(31)22(23(14)26)15-5-4-8-21(24(15)32)37-28(39)16-6-3-7-19(33)25(16)36-29(37)40/h3-12,35,41H,1-2H3,(H2,34,38)(H,36,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company
US Patent
| Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), ATP... |
US Patent US9334290 (2016)
BindingDB Entry DOI: 10.7270/Q2BK1B6S |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM230118
(US10106559, Example 47 | US10435415, Example 47 | ...)Show SMILES CC(C)(O)c1ccc2c(c1)[nH]c1c(cc(Cl)c(-c3cccc(c3Cl)-n3c(=O)[nH]c4c(F)cccc4c3=O)c21)C(N)=O |(-8.37,.74,;-7.03,1.51,;-6.64,.02,;-7.8,2.85,;-5.49,1.51,;-4.59,.27,;-3.06,.43,;-2.43,1.83,;-3.34,3.08,;-4.87,2.92,;-2.43,4.33,;-.97,3.85,;.37,4.62,;1.7,3.85,;1.7,2.31,;3.03,1.54,;.37,1.54,;.37,,;-.97,-.77,;-.97,-2.31,;.37,-3.08,;1.7,-2.31,;1.7,-.77,;3.03,,;3.03,-3.08,;3.03,-4.62,;1.7,-5.39,;4.37,-5.39,;5.7,-4.62,;7.03,-5.39,;7.03,-6.93,;8.37,-4.62,;8.37,-3.08,;7.03,-2.31,;5.7,-3.08,;4.37,-2.31,;4.37,-.77,;-.97,2.31,;.37,6.16,;1.7,6.93,;-.97,6.93,)| Show InChI InChI=1S/C30H21Cl2FN4O4/c1-30(2,41)13-9-10-14-20(11-13)35-26-17(27(34)38)12-18(31)22(23(14)26)15-5-4-8-21(24(15)32)37-28(39)16-6-3-7-19(33)25(16)36-29(37)40/h3-12,35,41H,1-2H3,(H2,34,38)(H,36,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A... |
US Patent US10435415 (2019)
BindingDB Entry DOI: 10.7270/Q2C53P6V |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM230118
(US10106559, Example 47 | US10435415, Example 47 | ...)Show SMILES CC(C)(O)c1ccc2c(c1)[nH]c1c(cc(Cl)c(-c3cccc(c3Cl)-n3c(=O)[nH]c4c(F)cccc4c3=O)c21)C(N)=O |(-8.37,.74,;-7.03,1.51,;-6.64,.02,;-7.8,2.85,;-5.49,1.51,;-4.59,.27,;-3.06,.43,;-2.43,1.83,;-3.34,3.08,;-4.87,2.92,;-2.43,4.33,;-.97,3.85,;.37,4.62,;1.7,3.85,;1.7,2.31,;3.03,1.54,;.37,1.54,;.37,,;-.97,-.77,;-.97,-2.31,;.37,-3.08,;1.7,-2.31,;1.7,-.77,;3.03,,;3.03,-3.08,;3.03,-4.62,;1.7,-5.39,;4.37,-5.39,;5.7,-4.62,;7.03,-5.39,;7.03,-6.93,;8.37,-4.62,;8.37,-3.08,;7.03,-2.31,;5.7,-3.08,;4.37,-2.31,;4.37,-.77,;-.97,2.31,;.37,6.16,;1.7,6.93,;-.97,6.93,)| Show InChI InChI=1S/C30H21Cl2FN4O4/c1-30(2,41)13-9-10-14-20(11-13)35-26-17(27(34)38)12-18(31)22(23(14)26)15-5-4-8-21(24(15)32)37-28(39)16-6-3-7-19(33)25(16)36-29(37)40/h3-12,35,41H,1-2H3,(H2,34,38)(H,36,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A... |
US Patent US9850258 (2017)
BindingDB Entry DOI: 10.7270/Q27S7R2C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM230118
(US10106559, Example 47 | US10435415, Example 47 | ...)Show SMILES CC(C)(O)c1ccc2c(c1)[nH]c1c(cc(Cl)c(-c3cccc(c3Cl)-n3c(=O)[nH]c4c(F)cccc4c3=O)c21)C(N)=O |(-8.37,.74,;-7.03,1.51,;-6.64,.02,;-7.8,2.85,;-5.49,1.51,;-4.59,.27,;-3.06,.43,;-2.43,1.83,;-3.34,3.08,;-4.87,2.92,;-2.43,4.33,;-.97,3.85,;.37,4.62,;1.7,3.85,;1.7,2.31,;3.03,1.54,;.37,1.54,;.37,,;-.97,-.77,;-.97,-2.31,;.37,-3.08,;1.7,-2.31,;1.7,-.77,;3.03,,;3.03,-3.08,;3.03,-4.62,;1.7,-5.39,;4.37,-5.39,;5.7,-4.62,;7.03,-5.39,;7.03,-6.93,;8.37,-4.62,;8.37,-3.08,;7.03,-2.31,;5.7,-3.08,;4.37,-2.31,;4.37,-.77,;-.97,2.31,;.37,6.16,;1.7,6.93,;-.97,6.93,)| Show InChI InChI=1S/C30H21Cl2FN4O4/c1-30(2,41)13-9-10-14-20(11-13)35-26-17(27(34)38)12-18(31)22(23(14)26)15-5-4-8-21(24(15)32)37-28(39)16-6-3-7-19(33)25(16)36-29(37)40/h3-12,35,41H,1-2H3,(H2,34,38)(H,36,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company
US Patent
| Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A... |
US Patent US10106559 (2018)
BindingDB Entry DOI: 10.7270/Q2SF2Z7Q |
More data for this
Ligand-Target Pair | |
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