Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM246405'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM246405 (US9446130, 21) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@H]1CCn2c(C1)nnc2C(F)(F)F |r| Show InChI InChI=1S/C26H19F6N9O/c27-25(28,29)16-5-7-34-17(12-16)36-23(42)14-3-1-13(2-4-14)19-20-21(33)35-8-10-41(20)22(37-19)15-6-9-40-18(11-15)38-39-24(40)26(30,31)32/h1-5,7-8,10,12,15H,6,9,11H2,(H2,33,35)(H,34,36,42)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Assay Method B: BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy...				US Patent US9446130 (2016) BindingDB Entry DOI: 10.7270/Q22806H6
					More data for this Ligand-Target Pair