Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM264132'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM264132 (7-(2-Hydroxypropan-2-yl)-4-(3-(8-methoxy-1-methyl-...) Show SMILES COc1cccc2c1n(C)c(=O)n(-c1cccc(c1C)-c1ccc(C(N)=O)c3[nH]c4cc(ccc4c13)C(C)(C)O)c2=O |(8.25,-7.31,;6.91,-6.54,;6.91,-5,;8.25,-4.23,;8.25,-2.69,;6.91,-1.92,;5.58,-2.69,;5.58,-4.23,;4.25,-5,;4.25,-6.54,;2.91,-4.23,;1.58,-5,;2.91,-2.69,;1.58,-1.93,;.24,-2.69,;-1.09,-1.92,;-1.09,-.38,;.24,.38,;1.58,-.38,;1.98,1.1,;.24,1.93,;1.58,2.69,;1.58,4.23,;.24,5,;.24,6.54,;1.58,7.31,;-1.09,7.31,;-1.09,4.23,;-2.55,4.71,;-3.46,3.47,;-4.99,3.3,;-5.62,1.9,;-4.71,.65,;-3.18,.81,;-2.55,2.22,;-1.09,2.69,;-7.16,1.9,;-8.25,.81,;-6.76,.41,;-7.93,3.23,;4.25,-1.93,;4.25,-.38,)| Show InChI InChI=1S/C33H30N4O5/c1-17-19(8-6-10-25(17)37-31(39)23-9-7-11-26(42-5)29(23)36(4)32(37)40)20-14-15-22(30(34)38)28-27(20)21-13-12-18(33(2,3)41)16-24(21)35-28/h6-16,35,41H,1-5H3,(H2,34,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, INVITROGEN Corporation), fluoresceinated peptide (1.5 μM), A...				US Patent US9714234 (2017) BindingDB Entry DOI: 10.7270/Q2474CW0
					More data for this Ligand-Target Pair