Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM185700![]() (US10875847, Compound Oclacitinib | US9161939, 1a |...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Intervet Inc. US Patent | US Patent US10875847 (2020) BindingDB Entry DOI: 10.7270/Q2P55RMM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM185700![]() (US10875847, Compound Oclacitinib | US9161939, 1a |...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.53 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Zoetis Services LLC US Patent | Assay Description Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk... | US Patent US9161939 (2015) BindingDB Entry DOI: 10.7270/Q2CC0ZF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM185700![]() (US10875847, Compound Oclacitinib | US9161939, 1a |...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human recombinant JAK1 (852 to 1142 residues) by Z-Lyte assay | Bioorg Med Chem 27: 1497-1508 (2019) Article DOI: 10.1016/j.bmc.2019.02.029 BindingDB Entry DOI: 10.7270/Q2B27ZSZ | |||||||||||
More data for this Ligand-Target Pair |