Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM411426'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM411426 (US10385052, Example 7) Show SMILES FC(F)(F)[C@H](CC#N)OCC1CCC(CC1)N1C=CC(=O)C2C=Nc3[nH]ccc3C12 |r,wU:4.7,c:18,23,(7.54,2.43,;7.86,3.93,;9.32,4.41,;9,2.9,;6.71,4.96,;7.03,6.47,;8.5,6.94,;8.82,8.45,;5.25,4.49,;4,5.39,;2.67,4.62,;2.67,3.08,;1.33,2.31,;0,3.08,;0,4.62,;1.33,5.39,;-1.33,2.31,;-2.67,3.08,;-4,2.31,;-4,.77,;-5.33,0,;-2.67,0,;-2.67,-1.54,;-1.33,-2.31,;0,-1.54,;1.46,-2.02,;2.37,-.77,;1.47,.48,;0,0,;-1.33,.77,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
Nissan Chemical Corporation US Patent					Assay Description The JAK inhibitory activities of compounds of the present invention were measured.The enzymes (JAK1, JAK2, JAK3 and Tyk2) were purchased from Carna B...				US Patent US10385052 (2019) BindingDB Entry DOI: 10.7270/Q2154KC4
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