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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM50463795'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50463795
PNG
(CHEMBL4248202)
Show SMILES Cn1cc(cn1)-c1nn(C2CCCN(C2)C(=O)CC#N)c2ncnc(N)c12
Show InChI InChI=1S/C17H19N9O/c1-24-8-11(7-22-24)15-14-16(19)20-10-21-17(14)26(23-15)12-3-2-6-25(9-12)13(27)4-5-18/h7-8,10,12H,2-4,6,9H2,1H3,(H2,19,20,21)
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n/an/a 342n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system using TK-substrate...

Bioorg Med Chem 26: 4774-4786 (2018)


Article DOI: 10.1016/j.bmc.2018.04.005
BindingDB Entry DOI: 10.7270/Q26Q20XK
More data for this
Ligand-Target Pair