Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [574-1154]' and Ligand = 'BDBM493076'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [574-1154] (Homo sapiens (Human))	BDBM493076 ((E)-N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-...) Show SMILES O\N=C(\NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 |r,wU:20.23,wD:17.19,(-4.18,15.1,;-3.41,13.76,;-4.18,12.43,;-3.41,11.1,;-1.87,11.1,;-1.1,9.76,;-1.73,8.36,;-.59,7.32,;-.6,5.78,;.73,5.01,;2.07,5.77,;3.53,5.29,;4.44,6.53,;3.54,7.78,;2.08,7.31,;.75,8.09,;.43,9.59,;1.52,10.68,;3.01,10.29,;4.1,11.37,;3.7,12.86,;4.79,13.95,;6.28,13.55,;7.76,13.15,;2.21,13.26,;1.12,12.17,;-5.72,12.43,;-6.49,13.76,;-8.03,13.76,;-8.8,12.43,;-8.03,11.1,;-6.49,11.1,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...				US Patent US10981911 (2021) BindingDB Entry DOI: 10.7270/Q27P92G6
					More data for this Ligand-Target Pair