Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [574-1154]' and Ligand = 'BDBM493085'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [574-1154] (Homo sapiens (Human))	BDBM493085 (2-((1r,4r)-4-(2-((1H-Pyrazol-5-yl)methyl)imidazo[4...) Show SMILES N#CC[C@H]1CC[C@@H](CC1)n1c(Cc2ccn[nH]2)nc2cnc3[nH]ccc3c12 |r,wU:3.2,wD:6.9,(6.77,3.67,;5.28,4.07,;3.8,4.47,;2.71,3.38,;3.11,1.9,;2.02,.81,;.53,1.2,;.13,2.69,;1.22,3.78,;-.56,.12,;-2.09,.28,;-2.86,1.62,;-4.4,1.62,;-5.31,.37,;-6.77,.85,;-6.77,2.39,;-5.31,2.86,;-2.72,-1.12,;-1.58,-2.16,;-1.59,-3.7,;-.26,-4.47,;1.08,-3.71,;2.54,-4.19,;3.45,-2.95,;2.55,-1.7,;1.08,-2.17,;-.25,-1.39,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...				US Patent US10981911 (2021) BindingDB Entry DOI: 10.7270/Q27P92G6
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