Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [574-1154]' and Ligand = 'BDBM493087'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [574-1154] (Homo sapiens (Human))	BDBM493087 (2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihyd...) Show SMILES OC[C@H]1CC[C@@H](CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:5.8,27.31,wD:24.27,2.1,(-9.44,-1.05,;-8.67,.28,;-7.13,.28,;-6.36,-1.05,;-4.82,-1.05,;-4.05,.28,;-4.82,1.62,;-6.36,1.62,;-2.51,.28,;-1.74,1.62,;-2.51,2.95,;-.2,1.62,;.57,.28,;-.06,-1.12,;1.08,-2.16,;1.07,-3.7,;2.4,-4.47,;3.74,-3.71,;5.2,-4.19,;6.12,-2.95,;5.22,-1.7,;3.75,-2.17,;2.42,-1.39,;2.11,.12,;3.19,1.2,;4.68,.81,;5.77,1.9,;5.37,3.38,;6.46,4.47,;7.95,4.07,;9.44,3.67,;3.88,3.78,;2.8,2.69,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...				US Patent US10981911 (2021) BindingDB Entry DOI: 10.7270/Q27P92G6
					More data for this Ligand-Target Pair