Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [574-1154]' and Ligand = 'BDBM493089'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [574-1154] (Homo sapiens (Human))	BDBM493089 (2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihyd...) Show SMILES OCCNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:22.25,wD:19.21,(-7.9,-1.05,;-6.36,-1.05,;-5.59,.28,;-4.05,.28,;-3.28,1.62,;-4.05,2.95,;-1.74,1.62,;-.97,.28,;-1.6,-1.12,;-.46,-2.16,;-.47,-3.7,;.86,-4.47,;2.2,-3.71,;3.66,-4.19,;4.58,-2.95,;3.68,-1.7,;2.21,-2.17,;.88,-1.39,;.57,.12,;1.65,1.2,;3.14,.81,;4.23,1.9,;3.83,3.38,;4.92,4.47,;6.41,4.07,;7.9,3.67,;2.34,3.78,;1.26,2.69,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...				US Patent US10981911 (2021) BindingDB Entry DOI: 10.7270/Q27P92G6
					More data for this Ligand-Target Pair