Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [574-1154]' and Ligand = 'BDBM493106'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [574-1154] (Homo sapiens (Human))	BDBM493106 (Phenyl ((1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6...) Show SMILES O=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Oc1ccccc1 |r,wU:19.22,wD:16.18,(-2.78,4.17,;-3.55,2.83,;-2.78,1.5,;-1.24,1.5,;-.47,.17,;-1.1,-1.24,;.04,-2.27,;.04,-3.81,;1.38,-4.58,;2.71,-3.81,;4.18,-4.29,;5.08,-3.04,;4.18,-1.8,;2.71,-2.27,;1.38,-1.5,;1.06,0,;2.09,1.15,;3.59,.83,;4.63,1.97,;4.15,3.44,;5.18,4.58,;6.69,4.26,;8.17,3.86,;2.64,3.76,;1.61,2.61,;-5.09,2.83,;-5.86,1.5,;-7.4,1.5,;-8.17,.17,;-7.4,-1.17,;-5.86,-1.17,;-5.09,.17,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...				US Patent US10981911 (2021) BindingDB Entry DOI: 10.7270/Q27P92G6
					More data for this Ligand-Target Pair