Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [574-1154]' and Ligand = 'BDBM493109'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [574-1154] (Homo sapiens (Human))	BDBM493109 (2-((1r,4r)-4-(2-(2-Oxo-2-(pyrrolidin-1-yl)ethyl)im...) Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCCC1 |r,wU:18.21,wD:15.17,(-4.94,-.18,;-4.17,1.15,;-2.63,1.15,;-1.86,-.18,;-2.48,-1.59,;-1.34,-2.62,;-1.34,-4.16,;-.01,-4.93,;1.33,-4.16,;2.79,-4.63,;3.7,-3.39,;2.79,-2.14,;1.33,-2.62,;-.01,-1.85,;-.33,-.34,;.7,.8,;2.21,.48,;3.24,1.63,;2.77,3.09,;3.8,4.24,;5.3,3.92,;6.79,3.52,;1.26,3.41,;.23,2.27,;-4.94,2.49,;-4.31,3.9,;-5.46,4.93,;-6.79,4.16,;-6.47,2.65,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...				US Patent US10981911 (2021) BindingDB Entry DOI: 10.7270/Q27P92G6
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