Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM127669'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127669 (US10251889, Example 42 | US10758542, Example 42 | ...) Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1C[C@H](O)C[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C21H24FN5O2/c1-21(2,3)25-20(29)16-11-23-27-8-7-18(24-19(16)27)26-12-15(28)10-17(26)13-5-4-6-14(22)9-13/h4-9,11,15,17,28H,10,12H2,1-3H3,(H,25,29)/t15-,17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127669 (US10251889, Example 42 | US10758542, Example 42 | ...) Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1C[C@H](O)C[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C21H24FN5O2/c1-21(2,3)25-20(29)16-11-23-27-8-7-18(24-19(16)27)26-12-15(28)10-17(26)13-5-4-6-14(22)9-13/h4-9,11,15,17,28H,10,12H2,1-3H3,(H,25,29)/t15-,17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127669 (US10251889, Example 42 | US10758542, Example 42 | ...) Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1C[C@H](O)C[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C21H24FN5O2/c1-21(2,3)25-20(29)16-11-23-27-8-7-18(24-19(16)27)26-12-15(28)10-17(26)13-5-4-6-14(22)9-13/h4-9,11,15,17,28H,10,12H2,1-3H3,(H,25,29)/t15-,17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair