Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM127712'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127712 (US10251889, Example 85 | US10758542, Example 85 | ...) Show SMILES Fc1cc(OCCN2CCOCC2)cc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r| Show InChI InChI=1S/C26H31FN6O3/c27-19-14-18(15-21(16-19)36-13-10-31-8-11-35-12-9-31)23-2-1-6-32(23)24-5-7-33-25(30-24)22(17-28-33)26(34)29-20-3-4-20/h5,7,14-17,20,23H,1-4,6,8-13H2,(H,29,34)/t23-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.38	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127712 (US10251889, Example 85 | US10758542, Example 85 | ...) Show SMILES Fc1cc(OCCN2CCOCC2)cc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r| Show InChI InChI=1S/C26H31FN6O3/c27-19-14-18(15-21(16-19)36-13-10-31-8-11-35-12-9-31)23-2-1-6-32(23)24-5-7-33-25(30-24)22(17-28-33)26(34)29-20-3-4-20/h5,7,14-17,20,23H,1-4,6,8-13H2,(H,29,34)/t23-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127712 (US10251889, Example 85 | US10758542, Example 85 | ...) Show SMILES Fc1cc(OCCN2CCOCC2)cc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r| Show InChI InChI=1S/C26H31FN6O3/c27-19-14-18(15-21(16-19)36-13-10-31-8-11-35-12-9-31)23-2-1-6-32(23)24-5-7-33-25(30-24)22(17-28-33)26(34)29-20-3-4-20/h5,7,14-17,20,23H,1-4,6,8-13H2,(H,29,34)/t23-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair