Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM127806'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127806 (US10251889, Example 179 | US10758542, Example 179 ...) Show SMILES CC(C)[C@@H](CO)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H25F2N5O2/c1-13(2)18(12-30)26-22(31)16-11-25-29-9-7-20(27-21(16)29)28-8-3-4-19(28)15-10-14(23)5-6-17(15)24/h5-7,9-11,13,18-19,30H,3-4,8,12H2,1-2H3,(H,26,31)/t18-,19?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127806 (US10251889, Example 179 | US10758542, Example 179 ...) Show SMILES CC(C)[C@@H](CO)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H25F2N5O2/c1-13(2)18(12-30)26-22(31)16-11-25-29-9-7-20(27-21(16)29)28-8-3-4-19(28)15-10-14(23)5-6-17(15)24/h5-7,9-11,13,18-19,30H,3-4,8,12H2,1-2H3,(H,26,31)/t18-,19?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127806 (US10251889, Example 179 | US10758542, Example 179 ...) Show SMILES CC(C)[C@@H](CO)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H25F2N5O2/c1-13(2)18(12-30)26-22(31)16-11-25-29-9-7-20(27-21(16)29)28-8-3-4-19(28)15-10-14(23)5-6-17(15)24/h5-7,9-11,13,18-19,30H,3-4,8,12H2,1-2H3,(H,26,31)/t18-,19?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair