Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM127823'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127823 (US10251889, Example 196 | US10758542, Example 196 ...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O2/c1-13-17(9-14(23)11-24-13)19-3-2-7-28(19)20-6-8-29-21(27-20)18(12-25-29)22(31)26-15-4-5-16(30)10-15/h6,8-9,11-12,15-16,19,30H,2-5,7,10H2,1H3,(H,26,31)/t15-,16-,19?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127823 (US10251889, Example 196 | US10758542, Example 196 ...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O2/c1-13-17(9-14(23)11-24-13)19-3-2-7-28(19)20-6-8-29-21(27-20)18(12-25-29)22(31)26-15-4-5-16(30)10-15/h6,8-9,11-12,15-16,19,30H,2-5,7,10H2,1H3,(H,26,31)/t15-,16-,19?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127823 (US10251889, Example 196 | US10758542, Example 196 ...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O2/c1-13-17(9-14(23)11-24-13)19-3-2-7-28(19)20-6-8-29-21(27-20)18(12-25-29)22(31)26-15-4-5-16(30)10-15/h6,8-9,11-12,15-16,19,30H,2-5,7,10H2,1H3,(H,26,31)/t15-,16-,19?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair