Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM148367'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM148367 (US8962637, 92) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1 Show InChI InChI=1S/C35H36F3N7O2/c1-22-6-9-29(41-33(47)24-4-3-5-26(18-24)35(36,37)38)19-31(22)45-17-14-30-25(21-45)20-39-34(43-30)42-27-10-7-23(8-11-27)32(46)40-28-12-15-44(2)16-13-28/h3-11,18-20,28H,12-17,21H2,1-2H3,(H,40,46)(H,41,47)(H,39,42,43)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent					Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...				US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN
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