Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM230139' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM230139
(US10106559, Example 70 | US10435415, Example 70 | ...)Show SMILES Cc1c(cccc1-n1c(=O)cc2c(F)cccn2c1=O)-c1c(F)cc(C(N)=O)c2[nH]c3cc(CCO)ccc3c12 |(3.63,,;2.3,-.77,;.96,,;-.37,-.77,;-.37,-2.31,;.96,-3.08,;2.3,-2.31,;3.63,-3.08,;3.63,-4.62,;2.3,-5.39,;4.96,-5.39,;6.3,-4.62,;7.63,-5.39,;7.63,-6.93,;8.96,-4.62,;8.96,-3.08,;7.63,-2.31,;6.3,-3.08,;4.96,-2.31,;4.96,-.77,;.96,1.54,;2.3,2.31,;3.63,1.54,;2.3,3.85,;.96,4.62,;.96,6.16,;2.3,6.93,;-.37,6.93,;-.37,3.85,;-1.84,4.33,;-2.74,3.08,;-4.27,2.92,;-4.9,1.51,;-6.39,1.11,;-7.48,2.2,;-8.96,1.8,;-3.99,.27,;-2.46,.43,;-1.84,1.83,;-.37,2.31,)| Show InChI InChI=1S/C30H22F2N4O4/c1-15-17(4-2-6-23(15)36-25(38)14-24-20(31)5-3-10-35(24)30(36)40)26-21(32)13-19(29(33)39)28-27(26)18-8-7-16(9-11-37)12-22(18)34-28/h2-8,10,12-14,34,37H,9,11H2,1H3,(H2,33,39) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company
US Patent
| Assay Description The assays were performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substrates ... |
US Patent US9334290 (2016)
BindingDB Entry DOI: 10.7270/Q2BK1B6S |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM230139
(US10106559, Example 70 | US10435415, Example 70 | ...)Show SMILES Cc1c(cccc1-n1c(=O)cc2c(F)cccn2c1=O)-c1c(F)cc(C(N)=O)c2[nH]c3cc(CCO)ccc3c12 |(3.63,,;2.3,-.77,;.96,,;-.37,-.77,;-.37,-2.31,;.96,-3.08,;2.3,-2.31,;3.63,-3.08,;3.63,-4.62,;2.3,-5.39,;4.96,-5.39,;6.3,-4.62,;7.63,-5.39,;7.63,-6.93,;8.96,-4.62,;8.96,-3.08,;7.63,-2.31,;6.3,-3.08,;4.96,-2.31,;4.96,-.77,;.96,1.54,;2.3,2.31,;3.63,1.54,;2.3,3.85,;.96,4.62,;.96,6.16,;2.3,6.93,;-.37,6.93,;-.37,3.85,;-1.84,4.33,;-2.74,3.08,;-4.27,2.92,;-4.9,1.51,;-6.39,1.11,;-7.48,2.2,;-8.96,1.8,;-3.99,.27,;-2.46,.43,;-1.84,1.83,;-.37,2.31,)| Show InChI InChI=1S/C30H22F2N4O4/c1-15-17(4-2-6-23(15)36-25(38)14-24-20(31)5-3-10-35(24)30(36)40)26-21(32)13-19(29(33)39)28-27(26)18-8-7-16(9-11-37)12-22(18)34-28/h2-8,10,12-14,34,37H,9,11H2,1H3,(H2,33,39) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description Compounds with activity against Jak2 tyrosine kinase have been observed to cause thrombocytopenia, anemia and neutropenia in human patients in clinic... |
US Patent US10435415 (2019)
BindingDB Entry DOI: 10.7270/Q2C53P6V |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM230139
(US10106559, Example 70 | US10435415, Example 70 | ...)Show SMILES Cc1c(cccc1-n1c(=O)cc2c(F)cccn2c1=O)-c1c(F)cc(C(N)=O)c2[nH]c3cc(CCO)ccc3c12 |(3.63,,;2.3,-.77,;.96,,;-.37,-.77,;-.37,-2.31,;.96,-3.08,;2.3,-2.31,;3.63,-3.08,;3.63,-4.62,;2.3,-5.39,;4.96,-5.39,;6.3,-4.62,;7.63,-5.39,;7.63,-6.93,;8.96,-4.62,;8.96,-3.08,;7.63,-2.31,;6.3,-3.08,;4.96,-2.31,;4.96,-.77,;.96,1.54,;2.3,2.31,;3.63,1.54,;2.3,3.85,;.96,4.62,;.96,6.16,;2.3,6.93,;-.37,6.93,;-.37,3.85,;-1.84,4.33,;-2.74,3.08,;-4.27,2.92,;-4.9,1.51,;-6.39,1.11,;-7.48,2.2,;-8.96,1.8,;-3.99,.27,;-2.46,.43,;-1.84,1.83,;-.37,2.31,)| Show InChI InChI=1S/C30H22F2N4O4/c1-15-17(4-2-6-23(15)36-25(38)14-24-20(31)5-3-10-35(24)30(36)40)26-21(32)13-19(29(33)39)28-27(26)18-8-7-16(9-11-37)12-22(18)34-28/h2-8,10,12-14,34,37H,9,11H2,1H3,(H2,33,39) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description The assays were performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra... |
US Patent US9850258 (2017)
BindingDB Entry DOI: 10.7270/Q27S7R2C |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM230139
(US10106559, Example 70 | US10435415, Example 70 | ...)Show SMILES Cc1c(cccc1-n1c(=O)cc2c(F)cccn2c1=O)-c1c(F)cc(C(N)=O)c2[nH]c3cc(CCO)ccc3c12 |(3.63,,;2.3,-.77,;.96,,;-.37,-.77,;-.37,-2.31,;.96,-3.08,;2.3,-2.31,;3.63,-3.08,;3.63,-4.62,;2.3,-5.39,;4.96,-5.39,;6.3,-4.62,;7.63,-5.39,;7.63,-6.93,;8.96,-4.62,;8.96,-3.08,;7.63,-2.31,;6.3,-3.08,;4.96,-2.31,;4.96,-.77,;.96,1.54,;2.3,2.31,;3.63,1.54,;2.3,3.85,;.96,4.62,;.96,6.16,;2.3,6.93,;-.37,6.93,;-.37,3.85,;-1.84,4.33,;-2.74,3.08,;-4.27,2.92,;-4.9,1.51,;-6.39,1.11,;-7.48,2.2,;-8.96,1.8,;-3.99,.27,;-2.46,.43,;-1.84,1.83,;-.37,2.31,)| Show InChI InChI=1S/C30H22F2N4O4/c1-15-17(4-2-6-23(15)36-25(38)14-24-20(31)5-3-10-35(24)30(36)40)26-21(32)13-19(29(33)39)28-27(26)18-8-7-16(9-11-37)12-22(18)34-28/h2-8,10,12-14,34,37H,9,11H2,1H3,(H2,33,39) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company
US Patent
| Assay Description Compounds with activity against Jak2 tyrosine kinase have been observed to cause thrombocytopenia, anemia and neutropenia in human patients in clinic... |
US Patent US10106559 (2018)
BindingDB Entry DOI: 10.7270/Q2SF2Z7Q |
More data for this Ligand-Target Pair | |