Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM419640'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM419640 (US10463675, Example 83 | US10980815, Ex. No. 83 | ...) Show SMILES Cn1cc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C2(CC#N)CN(C2)S(C)(=O)=O)cn1 |r,TLB:9:11:18:15.14| Show InChI InChI=1S/C20H27N9O2S/c1-26-10-15(9-23-26)24-19-22-8-5-18(25-19)27-11-16-3-4-17(12-27)29(16)20(6-7-21)13-28(14-20)32(2,30)31/h5,8-10,16-17H,3-4,6,11-14H2,1-2H3,(H,22,24,25)/t16-,17+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US10463675 (2019) BindingDB Entry DOI: 10.7270/Q2VT1VGN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM419640 (US10463675, Example 83 | US10980815, Ex. No. 83 | ...) Show SMILES Cn1cc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C2(CC#N)CN(C2)S(C)(=O)=O)cn1 |r,TLB:9:11:18:15.14| Show InChI InChI=1S/C20H27N9O2S/c1-26-10-15(9-23-26)24-19-22-8-5-18(25-19)27-11-16-3-4-17(12-27)29(16)20(6-7-21)13-28(14-20)32(2,30)31/h5,8-10,16-17H,3-4,6,11-14H2,1-2H3,(H,22,24,25)/t16-,17+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PC35J0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM419640 (US10463675, Example 83 | US10980815, Ex. No. 83 | ...) Show SMILES Cn1cc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C2(CC#N)CN(C2)S(C)(=O)=O)cn1 |r,TLB:9:11:18:15.14| Show InChI InChI=1S/C20H27N9O2S/c1-26-10-15(9-23-26)24-19-22-8-5-18(25-19)27-11-16-3-4-17(12-27)29(16)20(6-7-21)13-28(14-20)32(2,30)31/h5,8-10,16-17H,3-4,6,11-14H2,1-2H3,(H,22,24,25)/t16-,17+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US10980815 (2021) BindingDB Entry DOI: 10.7270/Q2XD14SG
					More data for this Ligand-Target Pair