Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM455539'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM455539 ((R)-3-(4-(4-(1-((S)-1- cyclopropylbutan-2-yl)- 1H-...) Show SMILES CC[C@@H](CC1CC1)n1cc(cn1)-c1cnn2cc(ncc12)-c1cnn(C[C@@H](O)CO)c1 |r| Show InChI InChI=1S/C22H27N7O2/c1-2-18(5-15-3-4-15)28-11-16(6-25-28)20-8-26-29-13-21(23-9-22(20)29)17-7-24-27(10-17)12-19(31)14-30/h6-11,13,15,18-19,30-31H,2-5,12,14H2,1H3/t18-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020) BindingDB Entry DOI: 10.7270/Q2CC13R9
					More data for this Ligand-Target Pair