Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50527920'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50527920 (CHEMBL4466247) Show SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(cccc12)C(=O)Nc1ccc(C)nc1C Show InChI InChI=1S/C26H26N8O2/c1-14-11-28-26(31-21-13-34(4)33-25(21)36-5)32-22(14)19-12-27-23-17(19)7-6-8-18(23)24(35)30-20-10-9-15(2)29-16(20)3/h6-13,27H,1-5H3,(H,30,35)(H,28,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-labeled GEEPLYWSFPAKKK-NH2 pep...				J Med Chem 63: 4517-4527 (2020) Article DOI: 10.1021/acs.jmedchem.9b01392 BindingDB Entry DOI: 10.7270/Q21V5JDF
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