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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50533683'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50533683
PNG
(CHEMBL4454640)
Show SMILES NC(=O)c1cnc(Nc2cnccn2)cc1NC1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C21H21N9O/c22-10-14-1-2-20(27-11-14)30-7-3-15(4-8-30)28-17-9-18(26-12-16(17)21(23)31)29-19-13-24-5-6-25-19/h1-2,5-6,9,11-13,15H,3-4,7-8H2,(H2,23,31)(H2,25,26,28,29)
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PC cid
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Article
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n/an/a 4.10n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of human JAK2 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISA

Bioorg Med Chem 24: 4711-4722 (2016)


Article DOI: 10.1016/j.bmc.2016.08.007
BindingDB Entry DOI: 10.7270/Q2RJ4NZW
More data for this
Ligand-Target Pair