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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50533708'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50533708
PNG
(CHEMBL4458964)
Show SMILES Cc1nn(CCCCCC#N)nc1-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H17N7/c1-11-13(14-12-6-8-17-15(12)19-10-18-14)21-22(20-11)9-5-3-2-4-7-16/h6,8,10H,2-5,9H2,1H3,(H,17,18,19)
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PC cid
PC sid
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Article
PubMed
n/an/a 165n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...


Bioorg Med Chem 24: 5036-5046 (2016)


Article DOI: 10.1016/j.bmc.2016.08.008
BindingDB Entry DOI: 10.7270/Q2C82DRC
More data for this
Ligand-Target Pair