Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50539818'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50539818 (CHEMBL4648612) Show SMILES Cc1[nH]nc2[nH]c(=O)cc(C3CC4CCC3CC4)c12 |(14.47,-21.16,;14.94,-22.62,;14.03,-23.86,;14.94,-25.12,;16.41,-24.64,;17.75,-25.4,;19.08,-24.64,;20.42,-25.41,;19.08,-23.09,;17.75,-22.31,;17.75,-20.77,;16.42,-20.01,;16.43,-18.46,;17.77,-17.7,;19.09,-18.48,;19.09,-20.01,;17.55,-20,;17.97,-18.46,;16.41,-23.09,)| Show InChI InChI=1S/C15H19N3O/c1-8-14-12(7-13(19)16-15(14)18-17-8)11-6-9-2-4-10(11)5-3-9/h7,9-11H,2-6H2,1H3,(H2,16,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
GVK Biosciences Private Limited Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged human JAK2 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assay				J Med Chem 63: 7008-7032 (2020) Article DOI: 10.1021/acs.jmedchem.0c00359 BindingDB Entry DOI: 10.7270/Q2JS9V08
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50539818 (CHEMBL4648612) Show SMILES Cc1[nH]nc2[nH]c(=O)cc(C3CC4CCC3CC4)c12 |(14.47,-21.16,;14.94,-22.62,;14.03,-23.86,;14.94,-25.12,;16.41,-24.64,;17.75,-25.4,;19.08,-24.64,;20.42,-25.41,;19.08,-23.09,;17.75,-22.31,;17.75,-20.77,;16.42,-20.01,;16.43,-18.46,;17.77,-17.7,;19.09,-18.48,;19.09,-20.01,;17.55,-20,;17.97,-18.46,;16.41,-23.09,)| Show InChI InChI=1S/C15H19N3O/c1-8-14-12(7-13(19)16-15(14)18-17-8)11-6-9-2-4-10(11)5-3-9/h7,9-11H,2-6H2,1H3,(H2,16,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
GVK Biosciences Private Limited Curated by ChEMBL					Assay Description Inhibition of JAK2 in human STAT5-irf1-bla TF1 cells assessed as reduction in EPO-induced STAT5-signalling pre-incubated for 1 hrs before EPO additio...				J Med Chem 63: 7008-7032 (2020) Article DOI: 10.1021/acs.jmedchem.0c00359 BindingDB Entry DOI: 10.7270/Q2JS9V08
					More data for this Ligand-Target Pair